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Vincent Fiore - Advisor, Tom Barker, PhD
"Understanding the Role of Extracellular Matrix (ECM) Mechanics in Guiding the Phenotype of Tissue-Resident Fibroblasts"
The ECM exists as a dynamic biochemical and mechanical environment, exerting tremendous influence on the phenotype of resident cells. Importantly, these properties can be drastically altered during pathogenesis, for example during fibrotic remodeling in the context of wound healing. The overall goal of this work is to understand how fibroblasts perceive mechanical cues from the ECM and how this may in turn modulate the underlying disease.