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"Tumor Lymphangiogenesis and its Implications in Metastasis, Immunity and Therapy"
Susan N. Thomas, PhD
School of Mechanical Engineering
The transport of fluids, biomolecules and cells from the tumor microenvironment to draining lymph nodes and into the circulation is facilitated by the lymphatic vascular system. This drainage process plays a pivotal role in disease progression, in particular by regulating both metastasis and adaptive immunity. Our efforts to characterize this contribution as well as to develop novel therapeutic approaches in tumor therapy that exploit the role of tumor lymphangiogenesis will be described.