- You are here:
- GT Home
Nathan Chiappa - Advisor, Edward Botchwey, PhD
"Computational Modeling of Modulation of Sphingolipid Metabolism by FTY720"
Sphingolipids play important physiological and pathological roles. Sphingolipid levels are controlled by a complex metabolic network. We have constructed a computational model of this network which allows for investigation of the effects of the immunomodulator FTY720 on sphingolipid metabolism in different cell types. The model results have important implications for potential therapeutic modulation of sphingolipid metabolism in many diseases.
Nick Willett, PhD - Advisor, Robert Guldberg, PhD
"Quantitative Screening of Novel Therapeutics to Treat Osteoarthritis"
Osteoarthritis (OA) is a large clinical burden with no interventions to modify disease progression. We evaluated two prospective disease modifying treatments in a surgically induced rat model of OA. This study demonstrated that EPIC-µCT has the sensitivity to evaluate the efficacy of OA therapies. The overall outcomes of this study will have a direct impact on the throughput for screening novel OA therapeutics in pre-clinical models.