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Po-Wei Chen - Advisor, Eberhard Voit, PhD
"Coordination of Rapid Sphingolipid Responses to Heat Stress in Yeast"
Like other organisms, the yeast Saccharomyces cerevisiae must respond to environmental stresses with a coordinated action that involves genes, proteins and metabolites. Using computer modeling, I characterize these responses from measured metabolic time series data.
Chanwoo Kim - Advisor, Hanjoong Jo, PhD
"Anti-inflammatory and Anti-atherogenic Role of BMP Receptor II in Endothelial Cells"
We found that loss of BMPRII causes endothelial inflammation and atherosclerosis by mechanisms mediated by reactive oxygen species, NFkB, and NADPH oxidases. These results suggest that BMPRII is a critical, anti-inflammatory and anti-atherogenic protein that is commonly targeted by multiple pro- and anti-atherogenic factors. BMPRII may be used as a novel diagnostic and therapeutic target in atherosclerosis.